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KMID : 0381219860180020147
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Journal of RIMSK
1986 Volume.18 No. 2 p.147 ~ p.156
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STI Changes in Halothane Anesthesia
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Abstract
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Halothane had been synthesized and introduced into clinical anesthesia from 1951 to 1956. Since then halothane has been one of the most commonly used inhalation anesthetic agent, although it has been well known that halothane acts directly on the myocardium and results in depression of myocardial contractility.
Recently, the STI(systolic time intervals) has become a new established myocardial function test, and is used widely in the various medical fields. So we tried to evaluate the effects of halothane anesthesia on the myocardial contractility by the use of STI. We measured the STI in resting alert state and in 1.5% halothane anesthesia with supine and 20 degree head-up tiling position from the 40 patients. The AVL 970 Myocard-Check was used for the measurement of STI in this study.
The results were as follow:
1) The STI values before anesthesia (control) were 546.5±16.8 msec for QS2C, 408.4±16.9 msec for LVETc, 138.1±16.6 msec for PEPc, 0.384±0.075 for PEP/LVET, and 54.7±12.4 for 1/PEPC´.
2) In the 1.5%halothane anesthesia with supine position there were significant increase
in QS2c, PEPc, PEP/LVET and decrease in 1/PEPC compared with the control values. (P<0.01) Therefore we concluded that 1.5% halothane anesthesia decreases the stroke volume and ejection fraction resulted chiefly from the depression of myocardial contractility.
3) After position change to 20 degree head-up tilting, there was increase in PEP/LVET without any changes in PEPc, LVETc, and l/PEPC(p<0.05). It seemed that 1.5% halothane anesthesia deteriorates the compensatory mechanism to pre load changes.
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